Combinations contacts
Concurrent expands in density of the many metabolites that have CBCL composite brutal score had a non-monotonic, upside-down You-designed trend, having lower CBCL element results within one another high minimizing quantiles of metabolite mixtures when compared to the median. But not, because all of the 95% CrI crossed 0, there have been no cumulative contacts within overall OPE metabolite mixture plus the internalizing, externalizing, and overall trouble intense ratings (come across Fig. 5A, C, and you can Elizabeth).
Profile 5 has: 1) the brand new projected difference in CBCL mixture get when function every metabolites for the percentile specified toward x-axis compared to form most of the metabolites on their median opinions (line step one), 2) this new univariate dating between for every metabolite and you can CBCL consequences, while you are almost every other metabolites is actually repaired from the its medians, and you may a carpet spot appearing the shipments of your own specified metabolite along side x-axis each and every panel (column 2). All patterns was basically modified to possess recruitment website, maternal years, race/ethnicity, house yearly earnings, degree, pre-pregnancy Body mass index, GA within sample range, child modified age at the CBCL administration, seasons, infant beginning acquisition, youngster sex. OPE metabolites and CBCL intense results was basically pure diary-switched, imply oriented, and you may important deviation scaled. Continued covariates was in fact mean-mainly based and you can practical deviation scaled. Note: BKMR, Bayesian Kernel Servers Regression; OPE, Organophosphate Ester; CBCL, Child Behavior Checklist; DPHP, Diphenyl phosphate; DNBP + DIBP, Sum of Di-n-butyl phosphate and you can Di-isobutyl phosphate; BDCIPP, Bis(step 1,3-dichloro-2-propyl) phosphate; BCEP, Bis(2-chloroethyl) phosphate; BBOEP, Bis(butoxethyl) phosphate